Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users

J Pujol; L Blanco-Hinojo; A Batalla; M López-Solà; BJ Harrison; C Soriano-Mas; JA Crippa; AB Fagundo; J Deus; R De la Torre; S Nogué; M Farré; M Torrens; R Martín-Santos

Journal article

Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users

J Pujol, L Blanco-Hinojo, A Batalla, M López-Solà, BJ Harrison, C Soriano-Mas, JA Crippa, AB Fagundo, J Deus, R De la Torre, S Nogué, M Farré, M Torrens, R Martín-Santos

Journal of Psychiatric Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014

DOI: 10.1016/j.jpsychires.2013.12.008

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Abstract

Background: Recreational drugs are generally used to intentionally alter conscious experience. Long-lasting cannabis users frequently seek this effect as a means to relieve negative affect states. As with conventional anxiolytic drugs, however, changes in subjective feelings may be associated with memory impairment. We have tested whether the use of cannabis, as a psychoactive compound, is associated with alterations in spontaneous activity in brain networks relevant to self-awareness, and whether such potential changes are related to perceived anxiety and memory performance. Methods: Functional connectivity was assessed in the Default and Insula networks during resting state using fMRI in 2..

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University of Melbourne Researchers

Ben Harrison Author

Related Projects (1)

Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported in part by Ministerio de Sanidad y Consumo, PNSD PI101/2006, PI041731/2011 and SOC/3386/2004 and Fondo de Investigacion Sanitaria, ISCIII-FEDER, RTA:RD06/0001/1009. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Groups SGR 2009/718, 1435 and 1450. Ms. Blanco-Hinojo is supported by the PFIS grant FI10/00387 from the Carlos III Health Institute. Dr. Lopez-Sola is supported by the FPU grant AP2005-0408 from the Ministry of Education of Spain. Dr. J.A. Crippa receives a CNPq (Brazil) productivity award (1B). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509).